Pregnenolone: The Forgotten Hormone
Understanding pregnenolone's role as the mother hormone and its effects on cognition, mood, and neurological health.
Pregnenolone, often called the "mother hormone," is the precursor to all steroid hormones including DHEA, testosterone, progesterone, cortisol, and estrogen. Despite its foundational importance, it's often overlooked in hormone optimization protocols.
Like other hormones, pregnenolone levels decline significantly with age. By age 75, levels may be 60% lower than in youth. This decline can affect multiple downstream hormone pathways and contribute to age-related cognitive and mood changes.
Pregnenolone has direct effects beyond hormone production. It functions as a neurosteroid, influencing brain function, memory, and mood. Research suggests it may improve memory, reduce brain fog, enhance learning, and support overall cognitive function. Some studies show benefits for depression and anxiety.
Supplementation typically ranges from 10-100mg daily, though some individuals require higher doses for therapeutic effects. Because pregnenolone can convert to multiple downstream hormones, comprehensive hormone testing before and during supplementation is essential. The conversion pathways are complex and individual, meaning effects can vary significantly between people. Many practitioners use pregnenolone strategically to support overall hormone balance while optimizing downstream hormones with more targeted interventions.
Ready to Optimize Your Health?
Discover how personalized protocols tailored to your unique biology can transform your health and accelerate your longevity journey. Our membership programs provide access to cutting-edge therapies and one-on-one guidance.